View full article | Antimicrobial activity of a Unani eye drop formulation in experimentally induced corneal ulcer in rabbit’s eye
*Abdul Latif, MD1; Abdul Razique, MD1 and R. R. Sukul, MS2
1Department of Ilmul Advia, A.K.T. College, 2Institute of Ophthalmology, J.N. Medical College and Hospital, Aligarh Muslim University, Aligarh-202002, India.
Correspondence to: Abdul Razique – arazik_49@rediffmail.com
Submitted: 16 January 2010
Accepted for publication: 10 August 2010
Abstract
In the present study, the Unani eye drop (UED) formulation was prepared for its beneficial effects in infective conditions of the eyes. The UED was prepared from seven herbo-mineral ingredients. The clinically isolated strain of Staphylococcus aureus was used to detect the in-vitro antimicrobial activity of UED and standard drug (Moxifloxacin hydrochloride eye drop) after that the in-vivo antimicrobial activity of placebo, test drug and standard drug was also carried out on corneal ulcers in rabbit eyes. The in-vitro antimicrobial study showed that UED at a dose of 10 µl/disc showed antimicrobial activity against Staphylococcus aureus. The result of Unani eye drop formulation in the treatment of corneal ulcer was almost comparable to that of Moxifloxacin eye drops and showed significant (p<0.05) antimicrobial activity against control. The study revealed that UED formulation is a potential antimicrobial drug having antimicrobial activity against Staphylococcus aureus bacterial strain.
Key words: Unani eye drop, moxifloxacin, corneal ulcer, antimicrobial, placebo.
* Corresponding author. Dr. Abdul Latif, Associate Professor & Chairman, Department of Ilmul Advia (Unani Pharmacology & Pharmaceutical Sciences), Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, 202002, India, Telephones: 0091-571-2401007(office), 0091-9411491277 Email: abdullatifamu@gmail.com